In vitro pharmacological activity of the tetrahydroisoquinoline salsolinol present in products from Theobroma cacao L. like cocoa and chocolate
MF Melzig, I Putscher, P Henklein, H Haber - Journal of …, 2000 - Elsevier
MF Melzig, I Putscher, P Henklein, H Haber
Journal of ethnopharmacology, 2000•ElsevierCocoa and chocolate contain the tetrahydroisoquinoline alkaloid salsolinol up to a
concentration of 25 μg/g. Salsolinol is a dopaminergic active compound which binds to the
D2 receptor family, especially to the D3 receptor with a Ki of 0.48±0.021 μmol/l. It inhibits the
formation of cyclic AMP and the release of β-endorphin and ACTH in a pituitary cell system.
Taking the detected concentration and the pharmacological properties into account,
salsolinol seems to be one of the main psychoactive compounds present in cocoa and …
concentration of 25 μg/g. Salsolinol is a dopaminergic active compound which binds to the
D2 receptor family, especially to the D3 receptor with a Ki of 0.48±0.021 μmol/l. It inhibits the
formation of cyclic AMP and the release of β-endorphin and ACTH in a pituitary cell system.
Taking the detected concentration and the pharmacological properties into account,
salsolinol seems to be one of the main psychoactive compounds present in cocoa and …
Cocoa and chocolate contain the tetrahydroisoquinoline alkaloid salsolinol up to a concentration of 25 μg/g. Salsolinol is a dopaminergic active compound which binds to the D2 receptor family, especially to the D3 receptor with a Ki of 0.48±0.021 μmol/l. It inhibits the formation of cyclic AMP and the release of β-endorphin and ACTH in a pituitary cell system. Taking the detected concentration and the pharmacological properties into account, salsolinol seems to be one of the main psychoactive compounds present in cocoa and chocolate and might be included in chocolate addiction.
Elsevier
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